株式会社ガンキルファーマ 代表取締役 藤田 潤 メッセージ
株式会社ガンキルファーマ 代表取締役 藤田 潤 メッセージ

藤田 潤 Jun Fujita


国立がんセンター病院(医員)、米国国立癌研究所 フェロー、大阪大学医学部(癌研究施設)助教授、京都大学(医学研究科分子病診療学)教授、同附属病院遺伝子診療部部長を歴任し、現在、医師、医学博士、京都大学名誉教授。



・Fujita J他、Ha-ras oncogenes are activated by somatic alterations in human urinary tract tumours. Nature. 309, 464-466, 1984.

・Rhim JS他、Neoplastic conversion of human keratinocytes by adenovirus 12-SV40 virus and chemical carcinogens. Science. 232, 385-388, 1986.

・Fujita J 他、Activation of H-ras oncogene in rat bladder tumors induced by N-butyl-N-(4-hydroxybutyl)nitrosamine. J Natl Cancer Inst. 80, 37-43, 1988.

・Fujita J他、In vitro duplication and in vivo cure of mast cell-deficiency of Sl/Sld mutant mice by cloned 3T3 fibroblasts. Proc Natl Acad Sci USA. 86, 2888-2891, 1989.

・Nishiyama H他、A glycine-rich RNA-binding protein mediating cold-inducible suppression of mammalian cell growth. J Cell Biol. 137, 899-908, 1997.

・Higashitsuji H他、Reduced stability of retinoblastoma protein by gankyrin, an oncogenic ankyrin-repeatprotein overexpressed in hepatomas. Nat Med. 6, 96-99,  2000.

・Higashitsuji H他、A novel protein overexpressed in hepatoma accelerates export of NF-kB from the nucleus and inhibits p53-dependent apoptosis. Cancer Cell. 2,  333-346,2002.

・Higashitsuji H他、The oncoprotein gankyrin binds to MDM2/HDM2, enhancing ubiquitylation and degradationof p53. Cancer Cell. 8, 75-87, 2005.

・Gajjar M他、The p53 mRNA-Mdm2 interaction controls Mdm2 nuclear trafficking and is required for p53 activation following DNA damage. Cancer Cell. 21, 25-35,  2012.

・Masuda T他、Cold-inducible RNA-binding protein (Cirp) interacts with Dyrk1b/Mirkand promotes proliferationof immature male germ cells in mice. Proc Natl Acad Sci USA. 109, 10885-108890, 2012.

・Morf J他、Cold-inducible RNA-binding protein modulates circadian gene expressionposttranscriptionally. Science. 338, 379-83, 2012.

・Qiang X他、Cold-inducible RNA-binding protein (CIRP) triggers inflammatory responses in hemorrhagic shock and sepsis. Nat Med. 19, 1489-1495, 2013.

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